Cover Picture: Eur. J. Immunol. 10/10

J Immunol

Retinoic acid (RA), a well-known vitamin A metabolite, mediates inhibition of the IL-6driven induction of proinflammatory Th17 cells and promotes anti-inflammatory regulatory T cell generation in the presence of TGF-beta, which is mainly regulated by dendritic cells. To directly address the role of RA in Th17/regulatory T cell generation in vivo, we generated vitamin A-deficient (VAD) mice by c...

Cover Picture.

Mucosal Immunol

Loss of CD4(+) T cells in the gut is necessary but not sufficient to cause AIDS in animal models, raising the possibility that a differential loss of CD4(+) T-cell subtypes may be important. We found that CD4(+) T cells that produce interleukin (IL)-17, a recently identified lineage of effector CD4(+) T-helper cells, are infected by SIV(mac251)in vitro and in vivo, and are found at lower freque...

C2nr11689h 1010..1015

Water-soluble carbon nanoparticles were prepared by refluxing natural gas soot in concentrated nitric acid. The surface of the resulting nanoparticles was found to be decorated with a variety of oxygenated species, as suggested by spectroscopic measurements. Back potentiometric titration of the nanoparticles was employed to quantify the coverage of carboxylic, lactonic, and phenolic moieties on...

Cover Picture Story: Experiments with Modular State Spaces

The main analysis techniques for critical systems use state space exploration. However, one is often quickly limited by the so-called state space explosion problem, even if the systems models are relatively small. Several methods have been proposed to tackle this problem in order to get a manageable state space. One of these takes advantage of the modular structure of the model in order to buil...